<p>What is the cause and effect: Is the fact that Chicago kids are by and large “nerdy” that is causing your friend to be depressed or is that she is depressed (for what ever reason) and hence finds her classmates “nerdy and unappealing”. In a large population (over 1500 other persons in that year, and possibly classmates in other graduating years), I am sure that there are at least a few people who share the same interests or there is someone she can relate to. Could it be possible that her depression is causing her to be negative and turn off everyone else around her and hence she is not being able to relate to anyone? </p>
<p>I am not sure that the matter is not as crystal clear as being made i.e. Chicago is full nerdy kids and hence she is not able to make friends as they appear to live in a different planet. I am going to guess that you friend needs professional help (could be psychological or it could even be psychiatric). I think expecting people in CC to be able to give specific advice (steps 1, step 2…) may not be practical. She needs to use the counseling resources available, possibly talk to a Doctor who might be able to prescribe medicines for depression or refer her to psychiatrist if needed. I would suggest that trained professional is the best bet.</p>