What will you do with your bio major, which is typically low paying?
Penn State is a huge name (if that’s what you are seeking) - it’s also different in geography than urban Columbia, BU, and NYU.
There are other urban schools if that’s what you seek - from a Pitt, UMN, College of Charleston, etc.
I honestly think you’re missing little academically, if anything. Rankings are to sell magazines.
How about excel at Penn State, have a great experience, and forget about leaving. If you already have one foot out the door, how can your experience be optimal - and that includes academically.