In a word, maybe
You may be asked for interim grades during the review process but not all applicants are.
Cal Poly SLO is absurdly competitive transfer destination. I know a student accepted to UCLA UCD and UCSB but rejected from SLO last year. Unlike most CA publics, they simply don’t admit alot of transfer students -just 1400 last year.
http://admissions.calpoly.edu/prospective/profile.html
No matter your stats, be sure to apply elsewhere.