For what it is worth, UCB is ranked #22 while USC is #24 in the latest USNWR rankings, negligible. The previous 2 years, they were tied at #22 and a year prior both tied at #21. If you are looking at the global reputation, UCB is more renowned due to the graduate school programs. However, you get an excellent education at either school.
In my opinion, UCB’s environment is more rigorous and cutthroat than at USC. In general, USC class sizes are smaller than UCB. In terms of safety, at both schools, students have to be vigilant and be aware of their surroundings. USC is very well patrolled by security and students get free Uber rides within the patrolled areas (about 2 mile radius).