Thanks for pointing that out Creekland. It looks like the program includes about 40 students per year?
https://www.rochester.edu/college/CCAS/students/opportunities/takefive/
out of a freshman class of 1405 that would be 2.8%. So looks like it may be a factor but not the whole explanation.
But even so, it really does beg the question: why do kids at U of R have a harder time graduating in 4 years that at peer institutions? To me the Take5 program is a symptom of that not a cause.
For example of the list posted in #3 here are the 4 year grad rates at the first 3 schools from #3 above
UChicago: 85.6%
WUStL: 86.4%
Emory: 82.9%
…
University of Rochester 74.2%
I usually find, whenever there is a mystery of this sort, the answer is usually connected to some sort of financial explanation…