U of C and Wash U are two great choices. Hyde Park is a great neighborhood, albeit somewhat isolated from the rest of Chicago. The CTA trains do not run to Hyde Park, so it is somewhat difficult to access the rest of the city.
The common core is not as stringent as when I attended, but it is not so easy to do all your pre-med work and do a non-bio/chem major. I ended up taking summer classes all 3 summers to get my pre-med requirements done.
JHU is extremely liberal with their gen ed/distribution requirements. It is the norm for students to double and triple major. The university wide culture promotes interdisciplinary research and undergrad students are encouraged to do the same. The Homewood neighborhood (JHU) is similar to Hyde Park (a wealthy enclave surrounded by rough urban areas), and I think Hyde Park is safer. However, I know lots of grad students at both places who were mugged, had cars broken into, apartments robbed, etc when living off campus in rougher sections of each neighborhood.
The Gothic architecture/Indiana limestone of U of C is amazing - hard to beat that! But JHU is one of the prettiest campuses I’ve toured on my kid’s college search. If you saw the movie The Social Network (about Facebook/mark zuckerberg) - JHU was the set for that movie, standing in for Harvard.