Weight loss drug thread for usage advice (not debating)

I use a brand called LMNT. They are sugar-free, but the taste is very salty. I will often use about half the packet in a 16 oz glass of water.

I have also used Liquid IV from Costco. They taste super sweet.

I tried electrolytes and could not get past the salty plus sweet taste. I’ve decided I don’t have a need; haven’t had any blood tests that indicate it, and I stay normally hydrated.

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I’m asking my Dr about weight loss management tomorrow. Hoping she’s open to a GLP but I’m frightened about muscle loss. I walk and do hand weights, I’d up that to gym work outs if she’d approve. Scheduled the meeting to talk about a Lilly trial for osteoarthritic knees and weight loss, it looks like it includes a GLP but I could end up with a placebo and I don’t want to stop the work I’ve put in so far to lose weight and build strength. Will have to see what the trial entails.

My husband has found that since he doesn’t feel hunger, having an empty stomach makes him feel terrible. He’s had an incident where he didn’t eat until late and that was a disaster. Now he knows he needs to not have an empty stomach during the day and to remember to have food at regular times

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Our SIL told my husband that having small meals throughout the day helped keep stomach issues at bay, so he’s followed that advice.

He stays hydrated, but that means getting up in the night.

I think we’re keeping Costco profitable what with the fair life protein drinks and Metamucil gummies purchases.

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There’s a podcast by a reputable metabolism doctor called Fat Science I listen to occasionally. The doc recommends “mechanical eating" – having a regular meal schedule that does not depend on hunger. Not because of it, but on my own, I developed a typical schedule of late morning breakfast, midafternoon light lunch, early dinner. It’s somewhat intermittent fasting, but gives me enough calories and nutrients and fits my preferences (very much not hungry in the morning, and want to avoid after dinner eating.) It’s also not set in stone; I stay flexible depending on circumstances. But I am intentional about making sure I do eat .

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If looking for a more natural electrolyte replacement drink, I like Coconut Water or similar (there’s a Kirkland version too).

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Saw my PCP (Internal Med doc) regardig a Lilly trial I saw for over 65, non diabetic, >25 BMI for osteoarthritis and weight loss…it did include a new GLP that is not on the market call Retatrutide. Anyway, doc said “no” she could not get me in the trial and strongly felt the osteoarthritis angle was likely to get more people into the trial and those who were doing well “knee wise” was due to the great weight loss. Apparently this glp kind has a rapid weight loss, no sure. So, what she did do was prescribe me the Wegovy pill a the lowest dose to see how I do on it and if it is tolerable with a 30 day follow up to see if I should continue or go up or quit. She said the pill is probably the slowest but the easiest to get off of if you don’t like side effects. Kind scared as the side effects are all over the map from none at to weird anxiety issues and loss of joy! I don’t want any of that. I start tomorrow. Pill was $149 with Good RX and next month, supposedly, will be $50 under Medicare - we shall see.

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I now know 2 people who have had weight loss surgery (covered by insurance) because their insurance no longer covers GLP1s. Make it make sense.

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I guess in the insurance company’s mind weight loss surgery is 1 and done as opposed to expensive drugs for potentially a life time.

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Based on supposed costs of gastric bypass surgery versus GLP-1 drugs, it is may be that gastric bypass surgery costs less than even just a few years of GLP-1 drugs.

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Gift link:

https://wapo.st/4anZCFq

A good overview of the promising new research about GLP-1s, cancer, and possibly other diseases.

”Although the studies involved different cancers and different treatments, they pointed to the same underlying hypothesis: that GLP-1s may alter the body’s inflammatory and metabolic environment in ways that make cancer therapies more effective.”

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This is fascinating. I wonder if systematic inflammation can also be an issue for people who aren’t obese? I’ll have to find this research.

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For me personally there’s a definite correlation with Zepbound and inflammation.

I have not been obese for 3 years now and only take the med monthly. On that third week my socks are tighter and I have ankle and wrist pain and if I get labs done my CRP is higher. All this resolved within 3 days post Zepbound and I’m totally pain free.

I also had weekly migraines and since I started Zepbound I may have one every 6-8 weeks.

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