@Denver5280, if your D takes AB next year, BC senior year would make the most sense. From my own research, 4 years of science is viewed very favorable by colleges, so for my D (Bio, chem, Physics first three years, no Honors option available at our school), it will be either AP Physics or AP Bio next year, depending on what would fit in her schedule.
I would also strongly recommend fitting in both APUSH and APEuro, even at the expense of Spanish Lit (unless she wants to double-major in Spanish). Maybe she could take Spanish Lit as a dual-enrollment class at a local community college to show her interest and aptitude?