I would be wary of calling Cal Poly a target for Biochem (and adjacent) majors. The admit rate for those is significantly lower than the overall admit rate there.
This is a bit hand-wavey, but the 2025–2026 Enrollment Projections data shows that they expect to matriculate 72 Biochem majors, and anticipate 1,713 applications. They have an overall yield rate of something like 30% (I’m not sure about the latest), so that ends up with an admit rate of something around …
(72 / 1,713) * (1 / .3) = ~14%
… so that’s about a 14% at most admit rate, and I would guess that the yield rate for popular majors like Biochem is even higher than the overall yield rate, so the admit rate for biochem could be closer to 10%.
Obviously, it’s up to you how you want to interpret the data there, but it could be worth factoring that in to the conversation.
[Edit: fixed link, per feedback just below this]