You might want to talk to your guidance counselor. I would be surprised if they think that the University of Michigan is a reach.
You cannot apply to two universities ED. Also, I think that your chances at U of Michigan (which is a great university) are high enough that I would not apply ED to Michigan State unless you actually clearly would prefer to attend Michigan State.
UC Berkeley and UCLA would probably be full pay. Are you okay with that? Given how strong the University of Michigan is, I do not see the point of being full pay out of state at UC Berkely or UCLA.
What is your intention for after getting a degree in Biology? Are you thinking of being premed?
To me you look like a very strong student. Good job!