I am not familiar with IL schools, but if you do not meet the minimum GPA requirement or test requirement needed to apply, yes you will be rejected. I suggest you do some research on the minimum application requirements for any schools of interest.
DePaul does not list a minimum GPA for application purposes so you might want to call to confirm before applying and they are test optional.
https://www.depaul.edu/admission-and-aid/types-of-admission/freshman-student/Pages/default.aspx