One of the most unique classes I took was a special topics course cross listed in CS and Philosophy called “Artificial Agents and Autonomy” - http://www.cs.tufts.edu/comp/150AAA/syllabus.html. It was co-taught by Daniel Dennett, a renowned philosopher on the faculty, and Matthias Scheutz, a professor of human-robot interaction with degrees in CS and philosophy. There are lots of cool opportunities at Tufts for this sort of cross-disciplinary learning.
Other somewhat unique classes I had were Bodyworks, a massage class (which may unfortunately no longer exist), and Comp 50 GD, a game design class involving students from both engineering and arts and sciences.