You also have UCB tagged on your post - which considers applicants using a holistic review process, so it is not all about grades.
Agreed, drop the ‘dream school’ and focus on what interests you and do your best.
Last thing - are you a CA resident? If not, you might want to consider the costs of attending a UC as an OOS student. While UPenn meets need, UC Berkeley will not.
Best to have a chat with your parents about what they will be able to afford for you as you start to grow your list.