An application is a portfolio of components. There’s no such thing as “making up for” something.
Yes, very strong ECs and AP Stats would be more attractive than weak ECs and AP Stats. But the same strong ECs and AP Calc would be stronger. Strengths in one area don’t make another area meaningless.
This doesn’t mean Calc is the right answer, just understand the reality of the tradeoffs. An A in Stats is probably better than a C in Calc. An A in Stats vs. a B in Calc could be an endless debate.