My cousin took anatomy and physiology a while back, and she told me that it was hard. Most of the course deals with memorization, so if you are not good at memorization, then it could be a bumpy ride. Like the others have said, the level of difficulty depends on the professor and you. The professor could make the class easier or harder. You have to be willing to devote time to memorizing all the material repeatedly. What may benefit you is if you form a study group with fellow classmates.