The key for us last time we visited, with kids, was being near a Metro station. We stayed in the 14th, just outside the 5/6/14 intersection. A quick walk to a station both to/from the airport and around the city. A hotel was much cheaper than one just a bit closer to the sights and an extra 10 minutes each morning/evening was a minor issue. Finding casual/~local places to eat was nicer than the tourist traps in the tourist areas.
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