In a general sense, the pickier one is, the less likely one will be able to find a job. Someone graduating with a major with few major-related job prospects but is only willing to look for major-related jobs with geographic limitations that do not include those where the few major-related jobs are is likely to be disappointed.
Even when one’s major does have more major-related job prospects, being geographically picky in excluding regions where such major-related jobs are more plentiful can limit one’s ability to get a job.