Well, of course college is not your one chance. Assuming that you are a traditional-aged college student, you’re around 18 years old now and will be around 22 when you graduate from college. You have your entire life to move elsewhere. North Dakota’s state universities are an especially good bargain; they are so inexpensive.
However, there’s nothing abnormal with wanting to move out of state, either! Lots of students want to. the University of Minnesota offers reciprocity: ND residents may MN resident rates, which is excellent because UMN is already very affordable for MN residents (resident tuition is about $12K per year).
There’s also the Midwestern Student Exchange Program, a program through which residents of 9 Midwestern states pay no more than 150% of the resident tuition rate at public universities in the other 8 states. Private colleges in the program give a 10% discount on tuition. You can see a list of schools [url=<a href=“http://msep.mhec.org/institutions?field_state_term_tid=4&field_program_type_term_tid=15&field_sector_term_tid=11&=View+Search+Results%5Dhere%5B/url”>http://msep.mhec.org/institutions?field_state_term_tid=4&field_program_type_term_tid=15&field_sector_term_tid=11&=View+Search+Results]here[/url]. Participating universities include IUPUI, Ball State, Indiana State, Wichita State, KU, UMKC, Truman State, all of the UW branch campuses except Madison, and University of Nebraska at Lincoln (among others).
@goldenbear2020 also referenced the WUE - which is a very similar program, but goes farther afield, all the way to the West Coast. Several Washington, Oregon, California, Colorado, Arizona, Alaska, Hawaii, and New Mexico campuses are included - including Western Washington University, Washington State University, University of Hawaii at Manoa, University of Alaska (Fairbanks and Anchorage), Portland State, many Cal State campuses, CU-Denver and CU-Colorado Springs, the University of Arizona, and some Arizona State campuses (excepting the main one at Tempe). (Utah, Idaho, Wyoming, Montana, South Dakota, and Nevada also participate in the program).
Man, I love living in the West 
Many large flagship universities are in small towns relative to the rest of the country - universities need space to sprawl, and many universities were granted their own land and town in the 1800s so they could build out. There are very few flagship universities located in big cities (although sometimes college towns have grown up around the universities - like Ann Arbor, Bellingham, or Athens). If you want a more urban feel, there are a lot of campuses on that list above that have more urban locations!
My recommendation is that if money is a concern for your family, apply to at least one of your state’s flagship campuses. It’s likely you’ll get in, since ND’s campuses are not very selective. It’s just a fallback - in case everything falls through. But select a couple of the WUE campuses that appeal to you and also look at some privates - maybe some that cover full financial need, if you have the stats for those schools, and then some where you’re in the top 25% or so of candidates, so you’re competitive for merit aid.