APs in the sophomore vs junior

I wanted to understand this one. How much does it help to spread out the rigor and workload? Does it help to take more APs in the sophomore year and have balance the junior year of high school?

For someone interested in Math/Science style focus and shooting for a top school, is taking APs earlier an advantage or delaying it till later a better strategy.
Should one have done AP Physics, AP Chem, AP Bio heading into the college application for say Bio Engineering.
Is it better to have 3 APs in math done before applying?

And how does it work if the grades don’t turn out just right(end up with A-s)