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<p>You don’t follow. Okay, for the sake of pleasing you let’s go with your idea that molecules to man is wrong. Yet it would be apparent that many aspects of evolution are correct – otherwise for example mtDNA analysis wouldn’t really work (yet it complements parallels historical linguistic analysis!) and correctly predicts many relationships (confirmed in other ways later). It correctly preducts how ecological environments fragment, unify, and so on. So many aspects of evolution must follow regardless of your theistic alignment. </p>
<p>Now note I used to be quite a fundamentalist Christian and didn’t object to the idea of a god behind the molecules. Of course that is no longer my primary belief for lack of evidence.</p>
<p>I also think you’re not really reading what I said. Evolution is fascinating regardless of your religious beliefs, and can be readily applied across many fields, unless you’re a Young Earth creationist or something.</p>
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<p>Umm, Circadian clocks are just a side note distraction I felt like harping on. Their historical development however is quite fascinating, esp. when you look at the homology between the Drosophila clock and the mammalian clock in terms of molecular clock components, but also how they have diverged significantly – flies phase delay with a light pulse in the early night and advance with a light pulse in the late night just like mammals but PER protein levels (PER is a critical rhythmic protein in the clock circuit – while per is the rhythmic transcript) are lowest in the midday for flies whereas mammals have highest PER levels in the day. </p>
<p>Yet all animals must have the same phase response behaviour or they can’t synchronise their clocks perfectly. No molecular clocks are perfectly 24 hours in period, many animals are slightly over or slightly under in terms of period, prolly cuz the Earth’s rotational period has been changing over time too, which makes phase responses frequent and necessary. (It’s funny cuz you’d think if there was a God he’d create a perfect clock, but apparently these animals have a clock that’s only “good enough”, even if it means putting the animal under phase response stress. but w/e) </p>
<p>But anyway, how this simultaneous convergence and divergence are achieved at the same time is explained by various neat discoveries. Fly PER is indirectly repressed by cryptochrome protein (CRY), which is activated by a light-mediated pathway – CRY destabilises TIM (which in turn stabilises PER and protects it from ubiquitin-mediated degradation by casein-kinase I aka DBT). But in mammals, CRY is found to stabilise PER, taking the place of TIM, and CRY has no light-sensitivity in mammals! The mammals themselves diverge; while the fly is small and transparent enough that light synchronises all the autonomous clocks in all the fly cells simultaneously without the need for a central neuroendocrine signal, birds rely on the pineal gland as a direct light synchroniser (yes, it is photosensitive because enough light reaches the bird brain even when covered with feathers); take out the pineal and the bird free runs. Mammals synchronise via the eyes, via rods and cones (and a third type of cell!) but via melanopsin – an invertebrate-type light receptor protein (whereas colour vision uses different proteins). Interesting choice of protein there, God…</p>
<p>Some organisms don’t even use the same clock circuit at all, but use an analogous circuit. Interestingly, cyanobacteria use a self-phosphorylating protein – the protein when phosphorylated is a phosphatase, but when fully dephosphorylated is a kinase. (This cute little feedback circuit has output signals), and the clock in plants and algae resembles this more. Funny you know, seems to support the endosymbiotic theory …</p>
<p>Merely suggesting that y’all take a Circadian clocks course sometime.</p>