<p>Could anyone explain the allosteric regulation in cellular respiration with the acetyl-CoA.</p>
<p>Thanks.</p>
<p>Sure. It’s not exactly typical allosteric regulation, however. Prior to the citric acid cycle (also called the Krebs cycle), pyruvate is transferred actively into the mitochondria. Within a multienzyme complex, a carboxyl group is removed from the pyruvate; the remaining two carbon molecule is then oxidized to form acetate. Coenzyme A is an allosteric regulator. It is attached to the acetate by an unstable bond. This serves as allosteric regulation because it activates the enzyme pyruvate carboxylase, which is used in the CA cycle as pyruvate is decomposed to oxaloacetate.</p>
<p>I remember it has something to do with NADH.</p>
<p>NADH is produced through the various processes throughout cellular respiration, but I don’t recall it ever being an allosteric regulator…</p>
<p>So what is the activator and what is the inhibitor?</p>
<p>Coenzyme-A (CoA) is the activator as it activates the enzyme pyruvate carboxylase as reesez said. I don’t think there is an inhibitor in there.</p>
<p>However, just to note, I haven’t seen anything like that on the numerous CB practice exams I’ve taken. It doesn’t get that advanced.</p>
<p>Thank you guys!</p>