It depends on whether or not you are a hooked student.
For example, if you are one of their top recruited athletes, or the child of a major donor, they are likely to overlook your imperfect grades (both this specific C+ as well as the 3.85 GPA from freshman to junior year.)
But this is not likely to be the case if you are unhooked. For these tippy-top schools, students in the “unhooked bucket” are academic superstars. They have plenty of 4.0 GPA National Merit scholars to choose from. So sure, apply anyway if this is where you really want to go, but do not expect to be offered admission.
There are plenty of other excellent schools where they would be glad to have you, 3.85 GPA and C+ and all. Make sure your list has some of these schools represented.