Canadian living in US Applying as 105D

HI I am wondering if there are any disadvantages that no one talks about for 105D applicants who live outside Canada. My daughter will be applying with online Canadian courses and US in-school courses. Really a mix of AP, honors and Canadian courses. She wants to go into premed or engineering…so math and science are important. But is there ANY disadvantage? Or is it just a way to categorize applicants as i have been told? She is flagged as a homeschooler here in the US for now.