<p>this is from my notes, almost verbatim from malkin’s mouth:</p>
<p>“This is an allosteric regulation, and it involved non-competitive inhibition. So that enzyme will stop working because E is there in sufficient concentration to prevent activity. But ultimately what is going to happen is that **the concentration of E is going to drop because it cannot be made; when that happens, that enzyme will start working again. **”</p>
<p>so it’s not gonna stop completely, it will start up again at a later time</p>
<p>post-translational modification refers specifically to affecting the activity of the proteins right? pretty sure that’s it, but i wanted to run it by someone…</p>
<p>edit: and this would be the reason glycosylation is NOT post-translation modification? because it doesn’t affect the ACTIVITY of the protein?</p>
<p>i think what it is is that there may be multiple subunits in the enzyme (making it allosteric as opposed to just regular non-comp which is one site shared by both substrate and inhibitor). so one inhibitor changes the structure of the enzyme if there is too much.
just my take dunno if it’s right htough… allosteric inhibition should stop completely; it wouldn’t make sense if it didn’t as you would ultimately still waste energy</p>
<p>post-translational modification of proteins involves a change in the physical structure of the protein (adding things, chopping things off, etc.). but you can deduce that a change in a protein’s structure also changes its function/activity as well.</p>
<p>well glycosylation is a change in physical structure but Malkin didn’t consider it post-translational modification though…</p>
<p>i have in my notes that glycosylation is post translational modification.</p>
<p>also: [Posttranslational</a> modification - Wikipedia, the free encyclopedia](<a href=“http://en.wikipedia.org/wiki/Posttranslational_modification]Posttranslational”>Post-translational modification - Wikipedia)</p>
<p>hmm okay, good save.</p>
<p>so to clarify, post-translational modification is change the physical structure of a protein after it is synthesized, so that is why glycosylation would fall under this definition.</p>
<p>HOWEVER, glycosylation is simply a way of targeting these proteins but does not modify the activity of them.</p>
<p>And the 2 processes that DO modify their behavior (which of course are also post-translational modification) are (1) Protein phosphorylation & (2) Proteolysis.</p>
<p>that sound about right?</p>
<p>JB stay up with me!!! lol</p>
<p>edit: we shoulda done this yesterday or something haha</p>
<p>si amigo.</p>
<p>anyways, i think i’m gonna sleep now. my eyelids are succumbing to the force of gravity. good luck to you and everyone else!</p>
<p>:( hey you too man, let’s give them hell</p>
<p>edit: any lurkers viewing this thread? lol. if so let’s continue this thread.</p>
<p>i’m a girl, but no biggie 
g’nite!</p>
<p>lol oops, i’ll remember that for next time</p>
<p>proceedddddddd but i’m reviewing the bookie and the manual and i kinda suck at this</p>
<p>okayyy im going to sleep
lets make a thread like this every midterm lol
good luck</p>
<p>Man, you Bio folks are so cooperative. Maybe premeds are not as competitive as everyone says they are.</p>
<p>lack of sleep is the cause of this decrease in cutthroatedness =P</p>
<p>more like if everyone fks up, mike meighan is just gonna tell us we suck and that he’s not gonna do a curve.</p>
<p>tell me about cytoskeleton! please someone.</p>
<p>oh crap, i forgot we have to do that, even though i remembered earlier in this thread rofl.</p>
<p>i’m just gonna wiki that an hour before the test lol</p>