Do colleges consider schedule difficulty as a factor?

<p>My calc grade is pretty low and it's senior year. (It's not senioritis, I try my best and get extra help but the way my teacher set her class grading sucks). I have 2 Ap classes and an Honors physics in my schedule. Will colleges even care as long as I don't fail? ( I have a 4.0 out of 4.0 weighted gpa atm excluding senior year).</p>