Eric Topol substack: An Exciting New Approach to Autoimmune Diseases

This looks really interesting although the science is light years ahead of my understanding of the science.



I saw that today as well. It would be amazing if it works.

That’s a very interesting article. Thanks for posting.

Seems like the important conceptual idea is in this quote from one of the pages linked by the linked page:

“The liver naturally marks molecules from broken-down cells with “do not attack” flags to prevent autoimmune reaction to cells that die by natural processes. [The glycosylation] coupled an antigen with a molecule resembling a fragment of an aged cell that the liver would recognize as friend, rather than foe.”

My kid has had type 1 diabetes for 29 years. I can’t tell you how many times we have read articles promising a cure from some new direction. We stopped "walking for a cure’ a long time ago. These articles are, frankly, painful. I have lupus but my concern is my daughter’s type 1 diabetes, the most misunderstood disease on the planet.


If this is the same one coming out of University of Chicago then I would believe it. Just need more human trials… Even if it just improves someone’s condition and not cure at this point would be huge. I am always skeptical but have trust in the researchers at University of Chicago.

Thank you for this. My husband and son both have celiac disease, which for the 20+ years post-dx they have promised some sort of permanent solution but nothing yet. In addition to celiac, S30 has a very rare (like, VERY rare) autoimmune malfunction for which he has been on a (at the time) fairly new T-cell moderator 20 yrs but they are switching him to Remicade which works entirely differently, so lots of anxiety about that. Autoimmune problems are easy to diagnose but hard to understand, as his doctor once said. Lots to research.


My kid has celiac as well, and probably RA. Once you have an autoimmune disease, you may end up with more.

I don’t think autoimmune diseases are easy to diagnose at all. People spend years trying to get a diagnosis. Lately I have high antibodies for scleroderma, along with the lupus diagnosis of 2001. Two docs said MS. I don’t care about labels. They are for insurance company codes.

Agreed. DH’s celiac was dx when we were all tested, after the kid was. The original dx for kid was JRA, then runaway celiac, then when a gf diet did not resolve issues, we were sent to progressively bigger hospitals. Eventually a succession of inpatient doctoring led us to one who knew what he was looking at and knew time was running out. I think his doctor’s point was not that this was easy, just that we can give a dx without necessarily understanding what went wrong or why.

Not having a science background, I read Donna Nakazawa’s Autoimmune Epidemic, and then Phillipp Dettmer’s Immune to help understand the what and how of immunesuppressing meds. Encouraged that research is making progress.