Oops, sorry. I just realized it is your daughter, not your son.
Both are definitely great schools. We visited both.
For business or nursing, I would lean towards Villanova.
For bio/neuroscience, I would lean towards HC. (Dr. Fauci’s alma mater 
!)
We visited A LOT of schools, and I tried to observe students as much as possible duiring every visit. Of all the schools we visited, I mentioned to my dughter that HC was one of the two schools where I felt students looked the happiest to be there. I got a friendly vibe. New athletic and arts centers there too, if that is of interest.
My D liked both schools, but felt like Villanova was more of a place where people got dressed up/put makeup on for class, and HC was more casual (t-shirt/jeans), which she liked better. She liked the area surrounding Villanova, but didn’t care for Worcester as much. I don’t feel like she would have ended up going to Boston that much, because it is a little bit of a hike (although I believe there is a bus for the students that makes it easy for them to get there on weekends). There is a train stop that goes to Philly right on the Villanova campus, which I thought was very cool and could be convenient.
And then of course there’s basketball, which is exciting at Villanova.
A $40k price difference would be significant for me, but I realize that may not be the case for everyone.
Best of luck to your daughter!