Selective colleges want to see a year each of bio, chem, and physics, plus one advanced classes. So no physics may be an issue.
As for AP vs DE, my own feeling is DE is fine for post-AP courses, but AP is preferred for the same-level , e.g. chem, since AP courses are a known commodity while DE quality varies by school.
For English though, since he is now taking AP Lang, I would be OK with DE English if it is a themed course - Shakespeare, American Drama, etc. But if it’s a general lit English 101 course, AP Lit is the better option IMO.
And be aware that DE credits likely will not transfer to ant OOS publics or to privates.