Since other have approached your question from a statistics angle I’ll throw in a different response- where I see your strengths and weaknesses.
GPA- Your freshman year GPA will hurt you. There’s no way around it. The upward trend will definitely help, but tippy top schools have so many students who have faced adversity and achieved top grades nevertheless that a 2.1 semester will provide a reason to put your application in the “no” pile. That doesn’t mean you can’t get into a fantastic school. It may just not be Stanford or a similar level school. I am sympathetic to your freshman year situation. To put my comments in context, my child’s sophomore year was rocky, as her dad was diagnosed with cancer that year and I (her mom) was was dealing with the emotional impact of his diagnosis, dealing with my own possible cancer recurrence, and spending all my time tending to a dying parent. Yeah, it was rough, and she suffered for it. I would urge you not to use up your essays on your mother’s absence but make sure your GC will address it. You want to look like someone who doesn’t indulge in self-pity but who has a logical reason for a grade drop.
Other stats- Your junior year GPA and ACT are very strong, as is the number of AP’s and your scores, so schools that look beyond your overall GPA may be interested. Are you looking at any LAC’s? They may be among your best bets for highly rated schools.
EC’s - When you talk about your work with the Pakastani nonprofit you may want to emphasize the number of donors you were able to attract instead of the dollars raised. At your parents’ income level the entire $1,500 could easily be self-funded. In a similar vein, your volunteer work in Pakistan could be misconstrued as noblesse oblige. It can be hard for admissions folks to differentiate between hardcore volunteers and voluntourists so you’ll either want to provide evidence that your work was more than a quick dip into volunteer work or make it a minor part of you application.
The pizza chain social media work is intriguing but in and of itself not necessarily impressive. It does make me wonder what your connection to the business is. It might make an interesting essay topic if you have a story to tell.
I like your essay topics, but make sure your essay is about you. That is, use the topic of education of women in Pakistan to tell the story of how you became activated and how you plan to move forward.
Good luck!