While I agree with everyone here who suggests getting your list preferences worked out first and then thinking about strategy, I understand your question to be one of understanding how a strategy could impact your outcome. All this info is ultimately necessary.
This will depend on the school and what your kid brings to them. It also depends on whether that B+/A- average is very good for your high school, what the rigor is, and what exceptional gifts your child will bring.
CALS is not simply TO, it is score free (for 1 more year), so if you think your D can put together a strong application there, is happy applying to a major (especially"a less popular:one), and you have an in-state tuition, it may not be a waste of an ED application. Without knowing your details, Tufts could be a harder sell – they have always been a bit more sensitive to stats, so that TO application will really need to be stellar. They like ED apps because they get so many strong students who use them as a back-up, so the “I will come” matters to them.
You are right to consider whether an ED application is possibly wasted. In general, the student should be a strong applicant to apply ED. And yes, there are a number of schools that are a bit less selective that fill most of their classes in the ED round, so you would be disadvantage in the RD round. In that case, it could be a great ED2 option.
Conn was one that our CC (several years ago) said had a strong ED lift for a good, but perhaps not exceptional student. That may be even more the case if you are FP.
I think, after your list is done, you can go back and strategize, using the details of each school. You may also want to seek out a few schools with rolling admissions or early notification so you can roll the ED dice without fear of being optionless in spring.
So in answer to your question, depending on what’s on your list, you might not want to use 2 ED slots on true reaches.