Mice immunized against multiple respiratory threats by "universal vaccine"

[ucbalumnus]

@Nina Bai of Stanford Medicine New Center

The new vaccine, for now known as GLA-3M-052-LS+OVA, mimics the T cell signals that directly stimulate innate immune cells in the lungs. It also contains a harmless antigen, an egg protein called ovalbumin or OVA, which recruits T cells into the lungs to maintain the innate response for weeks to months.

However, keeping the innate part of the immune system in a more active state for months may have unknown other effects.

One vaccine may provide broad protection against many respiratory infections...

Universal vaccine to treat colds, flu and COVID developed – and a new study...

https://www.science.org/doi/10.1126/science.aea1260

[Hippobirdy]

“They exposed the mice to a protein from house dust mites, a common trigger for allergic asthma. Allergic reactions are caused by a type of immune response known as Th2 response. Unvaccinated mice showed a strong Th2 response and mucus accumulation in their airways. The vaccine quelled the Th2 response and vaccinated mice maintained clear airways. ”

To have a nasal spray for seasonal allergies as well as dust mites wiuld be amazing. What would impact be on allergy clinics and their patients receiving immunotherapy for a variety of allergens such as pet dander and tree pollen?

[ucbalumnus]

The big question is, what disadvantage could there be for activating the innate immune system for months? Consider that if there were no disadvantage, would natural selection of selected in favor of keeping the innate immune system active continuously?