Midyear Grades????

First marking period of senior year ends in a few days for me. First question is, do I send my MP1 grades to my ED/EA school or wait for 2nd MP (which constitutes one semester)?
Secondly, I’m applying to schools like MIT and the Ivy’s. I’ve gotten mostly A’s throughout high school, with like a B+ or B in one subject every year. This year, for the first marking period, I have all A’s but two B+'s and possibly a C+/B- in an extremely hard class (multivariable calc). Is this going to kill my entire application?