Skipping bio in high school

I am currently at a well-known Los Angeles high school, going into junior year. We work on a physics-first schedule, so I’ve already taken physics (plan to take AP C senior year) and chemistry, but I have a choice this year and I couldn’t force myself to be interested in biology. I plan to take Hons. Precalc, AP English, APUSH, Hons. French 3 (easy for me), Theology (required), Junior Advisory (study hall), and either APES (which I’m interested in because I’d like to major in engineering of some kind) or biology (maybe AP, probably regular). From what I’ve heard, APES is easier than even regular bio, and not only am I somewhat interested, it’s also an AP course. If I entirely skip biology, will colleges care, and if so, would it look better than taking regular bio?

http://admission.universityofcalifornia.edu/counselors/files/csu-uc-a-g-comparison-matrix.pdf indicates that CSUs require one biological and one physical science, while UCs require at least two of biology, chemistry, and physics. So if you take chemistry and physics but not biology, you would meet the minimum requirements for UCs but not CSUs. However, it is not necessarily obvious whether the omission of biology would be a negative point when a UC admissions reader (or one at a highly selective private school) reads your application. Note: AP ES is listed in https://hs-articulation.ucop.edu/agcourselist#/list/search/institution as interdisciplinary science, rather than biological science.

For non-UC/CSU colleges, you may want to check their admission pages to see what they prefer.

For most engineering majors, physics is most important, then chemistry. Biology is obviously useful for biomedical and agricultural engineering; it may be useful for some areas of chemical, civil, and environmental engineering. Some colleges (e.g. MIT) have biology as a general education requirement, so attending them without high school biology may make college biology more painful.