Are you unfamiliar with the San Diego Tech and Health/Medical Pharma industry?
If you can afford to go to Cal poly and your parents are willing to pay for your housing and your travel expenses, then go for Cal Poly if you get in.
Driving in Southern California, 40 miles each way, will be a hassle for school. You will have some classes that are going to be in the evenings. Sitting in evening traffic, trying to get to class, is not fun. Oh and finding parking, DAILY, at San Diego State can be insane. You will have to get there very early (before classes), to find parking off of Montezuma or College Avenue.