You don’t have to go to a small liberal arts college to get small class sizes. My favorite college to recommend for pre-med is technically a research university, but it has only 6500 undergrads, has a student:faculty ratio of 9:1, and has class size under 20 for 80% of its classes. Classes over 50 are almost non-existent. Its faculty is world class, but it is nowhere near as difficult to gain admissions as the Ivy+ schools. In fact, it has been test optional since long before Covid.
I am talking about the University of Rochester, which sits just 4 hours directly north of Harrisburg. Best kept secret around. There is no specific major for pre-med anywhere. The range of options is wide. Nonetheless UR has long excelled in the biological sciences. They have close ties with the nearby hospital which serves as the training ground for the students in their med school. Research is definitely an option for their undergrads. It really has everything you’re looking for in an LAC.