Hm, though I would not have guessed either of these:
Santa Clara University: Founded in 1851 as Santa Clara College on the historic site of Mission Santa Clara de Asís, it was the first to actually begin instruction and hold continuous operations.
University of the Pacific: Originally chartered as California Wesleyan College on July 10, 1851, it holds the title of the oldest officially chartered college in the state, though it did not begin holding classes until 1852.
That’s not really correct for North Carolina. Really tired of these bad click bait lists, whether they are AI-generated or not.
Salem College started granting college diplomas in 1890 about 94 years after UNC-Chapel Hill did. Salem College is quite historic, but it was first called “The Little Girls School” when it was founded in 1772 to provide education to young girls. It was not a college for its first 100 years. Milestones - Salem College
I think UNC-Chapel Hill is the oldest actual college or university in North Carolina (certainly way older than Duke) but there may be some other smaller school that is older. According to Wikipedia UNC gave out its first diploma in 1796.