First, acceptance rate is not an indicator of being highly regarded. Being a small school can drive down acceptance rate, so can pushing for more applicants via mailings or marketing campaigns, and many other factors go into that. And even it was, Northeastern and CWRU have similar acceptance rates relatively. More relevantly, they have similar student profiles when it comes to GPA/SAT.
Secondly, a difference in general ranking of 10-20 spots in a ranking (a general one especially), let alone 2, is not meaningful. I don’t think you’re really considering any relevant criteria as you’ve listed it here.
Both Case and Northeastern are pretty STEM focused but also both have solid programs outside of STEM, so again I don’t think that criteria separates them.
The biggest difference between the two schools in my opinion:
Co-op: Do you like Northeastern’s co-op program?
Location: Cleveland vs Boston are very different despite both being cities
Honestly, these two schools are very similar. Can you visit both and talk to students/professors at each? This is a personal decision, not an objective one.