trusting doctors/studies

Since my previous post was too long, I won’t edit it, but will add it here. For someone my age, I take a lot of medications; genetics are not my friend in many ways (strong history of autoimmune disorders, high BP, very high cholesterol, heart disease at an early age, etc). I am on second and third generations of drugs that make them much easier to administer and be compliant with. I am pretty darned compliant; my morning meds are the most difficult because I can’t take anything (drugs or medication) within 30 minutes of taking my thyroid medication, so I’m always sure to get that one in, but sometimes three hours later I’ll go back in my bathroom and see my other two morning meds still sitting on the counter. Nighttime meds are easier because I can take them all at once. But I would LOVE it if they could develop a new formulary for Synthroid so that I didn’t have to time it with other medications. When my GERD is particularly bad, I temporarily add another medication called Carafate; I have to take it on an empty stomach, either one hour before eating, or 2-3 hours after eating, and not within two hours of my Nexium. It practically takes an algebraic equation to figure out when I can and can’t take my medications and/or eat. Again, it would make my life SOOOO much easier if the drug companies could come up with formularies that would eliminate these restrictions. I also use an estrogen hormone patch, but it only has to be changed twice a week - THANKFULLY!!! Otherwise, that’s another med, in either gel or cream form I’d have to rub into the forearm twice a day.

It’s human nature that the easier it is to maintain a schedule for taking medications, the more likely people are to be compliant and be healthy.

@teriwtt, you make good points.

I don’t know how much patients are going to benefit. With the product I mentioned, there is going to be some benefit with the administering of the drugs.

The prices are going to be much higher. I don’t know if the benefits are worth the additional costs.

My friend is very excited about the financial potential of this product and how much he can make. I am not hearing too much about the benefits for patients. :slight_smile:

I am not investing in this product. (My wife said no). :slight_smile:

I will know more in a year. :slight_smile:

“If the cost to manufacture the drug delivery product can be brought down, the patent on drugs using the new delivery product are going to be extended. Drug prices are going to increase.”

Not exactly. The new delivery system is not going to extend the existing patent on the active ingredient (API) itself, and a patent extension will not apply to the old API. A generic co is free to go ahead with their version of the drug as soon as the API patent expires. The customers (i.e. doctors) will be free to choose between an overpriced reformulated drug and the generic old formulation. If the benefit from reformulation is minimal, there will be no “transfer of wealth” you are talking about.

@BunsenBurner, you are probably correct. The improvement might be just enough to lead to much higher prices. I say this because this was the info I was given.

I guess I should have read the prospectus and more about the product and company. I would have more knowledge. It would make my friend happy if I did. He kept bugging me to read all this stuff.

Since I wasn’t going to invest, I declined.

If I knew months ago, I was going to post about this product, I would have read everything first. Too late. :slight_smile:

If the question is whether to invest in an individual something or not, wow, that’s a crapshoot. So, so many compounds with big promise never make it to market, for various reasons.

But I can tell you there are plenty of drugs out there which work fine as they are, but with some changes, could make it much easier for people to be compliant. There will always be a market (such as myself) of people who are on several medications who would love to make being compliant easier. So maybe by itself, it doesn’t seem like a big deal, but for people on multiple meds, one change could be very welcome and appreciated by patients.

And if you don’t invest in this product, and it still does really well, then be happy for the people who were looking for an easier way to be compliant and are keeping their personal health care costs down (therefore impacting your and my costs). With a mom and brother who both developed heart disease pretty much at my age now (other brother was a bit older), I figure every little thing I can do to delay or prevent heart disease, even if it means I pay a bit more for meds over the years, has GOT to be less than what was spent on my family that insurance had to pay out for hospital stays and procedures. And again, I am one of the compliant people, but I’m not getting younger, and I do realize being on several medications leaves more room for errors, the older I get. I don’t know what people did before pill boxes for each day of the week! I have five of them and dole out 4-5 weeks at a time, depending on whether or not I have enough of each med to complete five weeks, or have to do four. One of the first things I did when I got my first smart phone was to keep a ‘note’ of all the meds I’m currently on so every time I go to a doctor’s appointment and they ask, I can read them off with the current dosing and not worry I missed something. (three of my meds - Synthroid, estrogen patch, and statin - have changed doses in the last eight months and I can never keep the numbers straight, but I do want my doctors to see that I am doing everything I can to be compliant).

One more anecdote; a couple of years ago I was in the hospital with sepsis several weeks after my cancer diagnosis and hysterectomy. There are very few antibiotics my stomach can handle - I’m not necessarily allergic to them, but they will cause so much pain in my stomach that I absolutely refuse to take them. When they started talking about all these really serious antibiotics they were going to put me on, I warned them that I could have digestive issues that precluded me from taking them. In the 48 hours it took them to identify the bacteria I had (strep Group G), they’d had me on two antibiotics, then switched me to another once it was identified, but all through an IV. These were the last resort kinds of antibiotics, and I never had a moment of stomach issues with any of them! Of course, they had to send me home with a PICC line so I could administer my own antibiotic (I think it was ceftriaxone) twice daily for two weeks, but my stomach never made a peep. It gave me a sense of relief knowing if I ever really needed to have some of the heavy hitters, I could do so as long as they put a PICC line in! Yet I thought, “Man, they need to make this into a self-injectable so I wouldn’t have to get a PICC line if I ever needed it again.”

@teriwtt You are right. I understand this.

I am not going to be unhappy if the delivery product works. I will be happy for my friend and for people who benefit. A part of me will have wished I invested in the product. That is human nature. I will get over it. :slight_smile:

I have invested in a company that has a drug under development to combat these issues. I have no idea if this company’s drug will work. It is a crap shoot. Won’t effect my life financially if the drug works and won’t effect my life if the drug doesn’t. Just gambling.

Good luck to you. You have gone through a lot.