Last summer we were to take a family trip with our adult children, their spouse and toddlers; of course, it didn’t happen. We just decided about 2 weeks ago that we should go to the beach as the adults have all been vaccinated. We actually found a week that worked for all 6 adults the end of July, which was a miracle! I mentioned on another thread that due to the late decision, what I believe is the entire world wanted a vacation this year, and rental homes trying to recoup lost income from last year, we haven’t had much luck in finding a house we want.
We would like a house with a pool as it would be so much easier with the little girls, who will be 25 months and 33 months. While we would like to be a short walk to the beach, if there is a place to drop off the girls and a parent, the rest of us are willing to walk farther. Our family has either gone to Hilton Head or 30a, and would like to do the same, but 30a is packed, so during Covid, not sure we want to deal with that. We would cook most night, and do pick up the other; no plans to eat in a restaurant. So while we could go to a busy beach area, most likely other than at the beach, we won’t encounter many people. I would guess we would be at the beach in the early hours of the morning only, which is why a house with a pool would be nice. We would also consider a complex pool if it isn’t jam packed.
My son, wife and daughter just came back from a weekend at the beach, and it seems my son is no longer a fan of the beach. It became a joke that he couldn’t wait to get home and vacuum the sand out of his car! He said maybe we should think about a fly trip to somewhere like Denver where we could hike and run with the girls. We are all in three different states (kids in Texas and Louisiana, us Georgia) so if we drove, the panhandle of Florida is best, the South Carolina coast or nearby, as the kids would drive to us, spend the night, and we would drive the next day. One child would prefer a drive due to cost, the other would prefer to fly due to having a toddler 
Looking for ideas of a place that is somewhat Covid safe, something toddlers friendly, and a place the adult children might be able to escape from their children for a few hours while the grandparents are available to babysit!! Also, while not mandatory, I think my daughter would prefer to be near a decent hospital as her daughter has some severe food allergies. Being in a houseful of people, especially another toddler, she worried about her daughter getting a hold of something she shouldn’t.
Any suggestions for a location outside of Hilton Head or 30a that would fit the bill?
When I was a teenager, I went every year to Siesta Key with my aunt, uncle, and younger cousins as a babysitter. Free vacation for me, and some free time for my aunt and uncle!