It’s not just the level of the work, although it is hard - much harder than anything you will have done before - it’s the intensity. Oxford terms are just 8 weeks, and they cram more in than you would get in 10 or 12 weeks at an excellent university elsewhere. I don’t think a poor score in say Chem or Calc would disqualify you per se, but if it’s part of a pattern of lower grades than the typical Oxbridge applicant it is going to be noticed.
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