gpa matters how much?

I know the GPA matters a lot and especially big colleges consider it a lot.
So will a GPA of 4.5 and a GPA of 4.3 differ drastically?
Also do colleges look at GPA with a weighted scale or an unweighted scale?

Unweighted matters more than weighted expect for scholarships. Most colleges will recalculate your GPA on their own scale. 4.5 and 4.3 will differ as much as 4.0 and 3.8.