If I understood this correctly, Case Western would be about an extra $140,000 over four years. If you can afford to pay for Case Western in full, and you can also afford to pay a bit more than $400,000 for four years of medical school (let’s say $500,000 to be safe), and you can do this without taking on any debt and without any family hardship, then you can afford to not think about the cost of medical school. Most of us cannot afford to pay this much per child for an education.
A student really does not want to take on the full cost of medical school as debt. Even half of the cost of medical school as debt, with the parents paying the other half, is still a lot of debt.
Premed classes will be tough at any school on your list, and at pretty much any “top 200” university in the US. None of my immediate family was premed. One daughter however completed all of the required premed classes as a pre-vet student (the required undergraduate classes are the same). She is now a veterinarian. My other daughter completed most of these same required premed classes as a biology major. She is currently studying for a PhD in a biomedical field. I have heard plenty about how difficult the premed classes are, and how strong the other premed students are.
I do not think that there is any way around this. A premed student just needs to take the premed classes, work very, very hard, and do their best. A very hard earned B-, or even a C or two, in the toughest premed classes apparently does not necessarily keep a student out of medical school (nor apparently keep a student out of very good DVM programs).
Personally I would skip the two most expensive schools (Case and Baylor), choose from among the other four, and put any money saved into a bank account or 529 plan (or leave it in an already existing 529 plan, which is what we actually did) and keep any money saved in the bank for medical school.
The large majority of students who start off university thinking “premed” end up doing something else. Some students cannot keep up a medical-school-worthy GPA in the tough premed classes. Some however just find something else they would rather do. There are a lot of choices for “something else”. However, a significant number of these choices for something else do involve some form of graduate school, and having a bit of money in the bank for graduate school can be helpful regardless of what form of graduate school is chosen.
There are a lot of research opportunities at a lot of universities. However I do think this is important. This is of course one alternative to medical school that some originally premed students end up deciding is a better fit for them.
I think that I would look for the best fit among the four very good in-state options.
By the way, your prices at the in-state public options look like some merit aid might be included. Your daughter’s excellent set of acceptances overall look to me like she has done very well up to now. Congratulations!