Just an FYI for future applicants. We took the Amtrack, 8 hour ride to Buffalo the train was very comfortable going there. It made a lot of stops in between at places like Rochester, Syracuse, Pouhkipsie, Albany. It is half an hour a way from Niagra falls.
The school was really big (North Campus). We were able to tour the school without going outside much. The buildings are all connected with enclosed walkways.
If you get selected wear a suit or blazer. I know they said business casual but most of the kids had on full suits or blazers. Wear comfortable shoes because you may be doing a tour before or after your interview. The tour was only about one hour though so you should be ok either way. If for some reason you absolutely cannot make it for the interview, they do offer accommodations and you can do it through SKYPE.
I think it was well worth the trip to see how the honors college students interact and they had some professors in various subject areas talk to students and parents. It was also great seeing the area. We took one of the shuttles to see the South campus.
UBuff is huge but I feel that it had lots of opportunities. I think if you are in the honors college it would make the school feel a lot smaller. I think if you and t to something int he medical feel or sciences it would be a great place.